The attackers opened fire on the bus in Minya, the province’s bishop told AFP.
The gunmen “killed seven people and wounded 14, all of whom are in the Sheikh Fadel hospital in Beni Mazar” around 200 kilometres (120 miles) south of Cairo, said Bishop Makarios of Minya.
A security official confirmed the attack, adding that there were “dead and wounded”.
There was no immediate claim of responsibility for the shooting.
Copts, a Christian minority that make up 10 per cent of Egypt’s 96 million people, have in recent years been repeatedly targeted by the Islamic State jihadist group. Read more