Briton’s Kyle Edmund lost to US Open top seed Novak Djokovic, while compatriot Cameron Norrie advanced to the third round of a Grand Slam for the first time.
Edmund, 25, unexpectedly won the first set but ultimately struggled to keep up with the world number one’s intensity.
The 33-year-old maintained the level that has helped him stay unbeaten in 2020 and won 6-7 (5-7) 6-3 6-4 6-2.